Mechanisms of RNA processing and splicing
In this issue, we feature studies on RNA processing, including mechanisms of mRNA splicing, biogenesis of the splicing machinery, mRNA decoding by the ribosome, and mRNA deadenylation for degradation.
In this issue, we feature studies on RNA processing, including mechanisms of mRNA splicing, biogenesis of the splicing machinery, mRNA decoding by the ribosome, and mRNA deadenylation for degradation.
The molecular mechanisms that regulate the transition from totipotency into divergent cellular states are unclear. Two new studies show that the transcription factors TFAP2C, NR5A2 and TEAD4 (TNT) support the formation of a transient bipotent state by activating early pluripotency and trophectoderm genes and modulating HIPPO signaling.